Ibtrozi (taletrectinib), ROS1-positive NSCLC access
Locally advanced or metastatic ROS1-positive non-small cell lung cancer in adults ยท Oncology (ROS1-positive NSCLC)
About Ibtrozi
Ibtrozi (taletrectinib) is an oral next-generation ROS1 tyrosine kinase inhibitor from Nuvation Bio, dosed at 600 mg once daily. It is indicated for adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC), including patients previously treated with a first-generation ROS1 TKI. It earned US FDA approval in 2025.
Taletrectinib was designed to address resistance mutations and CNS progression that limit earlier ROS1 inhibitors, with a tolerability profile aimed at chronic daily dosing in a metastatic-disease setting.
Where Ibtrozi is not yet registered in a patient's home country, Reserve Meds coordinates supply from US specialty wholesalers via Named Patient Program (NPP) and personal-import pathways, against a destination-country prescription and the regulatory paperwork specific to each jurisdiction.
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How Reserve Meds coordinates Ibtrozi
- Patient or treating physician submits a named-patient request.
- Clinical team verifies appropriateness of Ibtrozi for the patient and destination country.
- Treating physician issues prescription and clinical justification.
- Country-specific NPP / personal-import documentation is prepared.
- Ibtrozi is sourced from a DSCSA-compliant US specialty wholesaler with full serial traceability.
- Shipment is coordinated to the patient's physician or hospital pharmacy (cold-chain where required).
Access by country
Reserve Meds publishes a detailed country deep-dive for Ibtrozi in every market we coordinate. Each page below covers the destination-country regulatory pathway (named-patient framework), real costs in local currency and USD, indicative timelines, physician-credential requirements, and cold-chain handling for the route into that country. Tap any country to read the full deep-dive.
Start a request for Ibtrozi
Submit a 60-second intake. Our clinical team will reach out as our first cohort opens with case-specific feasibility, timeline, and a formal quote.